Britain, European Security and the Cold War, 1976–9

PhDThis thesis deals with Britain’s attitude towards European security under the Callaghan government from 1976 to 1979. That period saw Cold War tensions grow and détente lose its momentum as Britain struggled with economic weakness while trying to maintain its international influence. Concentrating on Cold War Europe, this thesis asks two questions: what policy did the Callaghan government adopt towards European security, and what role did Britain play in the Atlantic Alliance? It draws three conclusions. First, under Callaghan, Britain sought to maintain a traditionally influential role in Europe. To achieve that goal, it attempted to sustain a major military contribution to NATO and to foster good US-UK relations. Nevertheless, this policy was complicated by acute economic crisis and defence expenditure cuts. Britain’s credibility in the Alliance was seriously diminished and policymakers had to offset reductions in British hardware contributions with diplomatic contributions. Secondly, Britain’s role as a mediator in the Alliance contributed to its stability during the presidency of Jimmy Carter. Carter’s inconsistent foreign policy and lack of consultation with allies caused confusion and tensions soon after his inauguration. This gave the British room to work for the maintenance of Alliance unity and, as a result, the US-UK special relationship was strengthened. Thirdly, regardless of Britain’s response to its economic trails, and its collaboration with the US, Callaghan’s preference for status quo, and his lack of strategy towards European security other than the maintenance of the stability of the Alliance under American leadership, hampered Britain’s attempts to retain influence. As Britain’s power waned, West Germany’s rose as German leaders gained status in the defence policy making process of the Alliance by arguing for a new response to the changing East-West military balance and the decline of détente.Japan Student Services Organization School of History, Queen Mary University of London, Stretton Fun

Construction of Tertiary Chiral Centers by Pd-catalyzed Asymmetric Allylic Alkylation of Prochiral Enolate Equivalents

The palladium-catalyzed decarboxylative allylic alkylation of enol carbonates derived from lactams and ketones is described. Employing these substrates with an electronically tuned Pd catalyst system trisubstituted chiral centers are produced. These stereocenters have been previously challenging to achieve using Pd complex/chiral P–N ligand systems

Perioperative Management of Hemophilia A Using Recombinant Factor VIII in Patients Undergoing Major or Minor Surgery

Among the surgical treatments performed in patients with hemophilia, joint surgery for intra-articular bleeding is the most time-consuming. Previous reports describe the perioperative management of hemophiliacs undergoing coronary artery bypass grafting or of those undergoing cystectomy for treatment of hematuria. In the former study, the patient was elderly; in the latter study, the authors concluded that cystectomy in hemophiliacs is safe if monitored appropriately and that urinary diversion using the intestine should be avoided because anastomotic hemorrhaging may occur. In this study, we discuss coagulation factor replacement therapy for patient with hemophilia A undergoing major or minor surgery

Impedance-matched High-overtone Bulk Acoustic Resonator

A high-overtone bulk acoustic resonator (HBAR), in which a piezoelectric transducer is set on an acoustic cavity, has been attracting attention in both fundamental research and RF applications due to its scalability, high frequency, and high quality factor. The acoustic impedance matching in HBARs is crucial for efficient acoustic power transfer from the piezoelectric transducer to the cavity. However, impedance mismatch remains in most HBARs due to the metal layer insertion between the piezoelectric layer and cavity substrate. In this study, we fabricated a nearly impedance-matched high-quality HBAR using an epitaxial AlN piezoelectric layer directly grown on a conductive SiC cavity substrate with no metal layer insertion. The small impedance mismatch was verified from the variation in the free spectral range (FSR), which is comparable to the best value in previously reported HBARs. The experimentally obtained FSR spectra was greatly reproduced by using the Mason model. Broadband phonon cavity modes up to the K-band (26.5 GHz) were achieved by reducing the thickness of the AlN layer from 800 to 200 nm. The high figure of merit of $f\times\text{Q} \sim 1.3\times 10^{13}\ \textrm{Hz}$ at 10 GHz was also obtained. Our nearly impedance-matched high-quality HBAR will enable the development of RF applications, such as low-phase noise oscillators and acoustic filters, as well as research on high-frequency acoustic systems hybridized with electric, optical, and magnetic systems

Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study

The kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive regulation, the so-called hypothalamic–pituitary–gonadal (HPG) axis. However, in nonmammalian vertebrates, especially in teleosts, existence of kisspeptin regulation on the HPG axis is still controversial. In this study, we applied multidisciplinary techniques to a teleost fish, medaka, and examined possible kisspeptin regulation on the HPG axis. First, we generated knockout medaka for kisspeptin-related genes and found that they show normal fertility, gonadal maturation, and expression of gonadotropins. Moreover, the firing activity of GnRH1 neurons recorded by the patch clamp technique was not altered by kisspeptin application. Furthermore, in goldfish, in vivo kisspeptin administration did not show any positive effect on HPG axis regulation. However, as kisspeptin genes are completely conserved among vertebrates except birds, we surmised that kisspeptin should have some important nonreproductive functions in vertebrates. Therefore, to discover novel functions of kisspeptin, we generated a gpr54-1:enhanced green fluorescent protein (EGFP) transgenic medaka, whose gpr54-1–expressing cells are specifically labeled by EGFP. Analysis of neuronal projection of gpr54-1:EGFP–expressing neurons showed that these neurons in the ventrolateral preoptic area project to the pituitary and are probably involved in endocrine regulation other than gonadotropin release. Furthermore, combination of deep sequencing, histological, and electrophysiological analyses revealed various novel neural systems that are under control of kisspeptin neurons—that is, those expressing neuropeptide Yb, cholecystokinin, isotocin, vasotocin, and neuropeptide B. Thus, our new strategy to genetically label receptor-expressing neurons gives insights into various kisspeptin-dependent neuronal systems that may be conserved in vertebrates

Periarticular Osteophytes as an Appendicular Joint Stress Marker (JSM): Analysis in a Contemporary Japanese Skeletal Collection

Objective: The aim of this study was to investigate the possibility that periarticular osteophytes plays a role as a appendicular joint stress marker (JSM) which reflects the biomechanical stresses on individuals and populations. Methods: A total of 366 contemporary Japanese skeletons (231 males, 135 females) were examined closely to evaluate the periarticular osteophytes of six major joints, the shoulder, elbow, wrist, hip, knee, and ankle and osteophyte scores (OS) were determined using an original grading system. These scores were aggregated and analyzed statistically from some viewpoints. Results: All of the OS for the respective joints were correlated logarithmically with the age-at-death of the individuals. For 70 individuals, in whom both sides of all six joints were evaluated without missing values, the age-standardized OS were calculated. A right side dominancy was recognized in the joints of the upper extremities, shoulder and wrist joints, and the bilateral correlations were large in the three joints on the lower extremity. For the shoulder joint and the hip joint, it was inferred by some distinctions that systemic factors were relatively large. All of these six joints could be assorted by the extent of systemic and local factors on osteophytes formation. Moreover, when the age-standardized OS of all the joints was summed up, some individuals had significantly high total scores, and others had significantly low total scores; namely, all of the individuals varied greatly in their systemic predisposition for osteophytes formation. Conclusions: This study demonstrated the significance of periarticular osteophytes; the evaluating system for OS could be used to detect differences among joints and individuals. Periarticular osteophytes could be applied as an appendicular joint stress marker (JSM); by applying OS evaluating system for skeletal populations, intra-skeletal and inter-skeletal variations in biomechanical stresses throughout the lives could be clarified